Blog

In the face of escalating antimicrobial resistance (AMR), researchers and innovators are turning to advanced technologies like Artificial Intelligence (AI) and genomic sequencing to pave new roads in the battle against superbugs.

In the wake of the upcoming UN General Assembly, the spotlight turns to a pressing global health challenge: antimicrobial resistance (AMR). 

Escherichia coli, commonly referred to as E. coli, is a familiar term to many. It is a rod-shaped bacterium that is typically found in the lower intestines of warm-blooded organisms, including humans.

Bacteria rely on a system called quorum sensing (QS) to sense population density and make collective decisions.

The 6M € granted to IN-ARMOR project will optimize an already developed drug platform using Computer Aided Drug Design. 

Vibiosphen’s constant objective is to develop innovative and translational experimental models that would ultimately result in the decrease of the number of animals used for preclinical testings.

By zooming in the mechanism that bacteria use to escape the antibiotics, we find three different subgroups – resistance – tolerance – persistence.

Distinguishing these three groups is key in the fight against bacterial infection.

A collaboration between 3 players : L’oréal – Qima – Vibiosphen

Our last collaboration led to a great publication to understand the aetiology of dandruff, and specifically the role of Malassezia restricta.

Acne vulgaris is a common inflammatory disorder affecting more than 80% of young adolescents. Cutibacterium acnes plays a role in the pathogenesis of acne lesions, although the mechanisms are poorly understood. 

Recent advances in sequencing technology have demonstrated that the development of AD not only associates with the skin microbiome, but also with gut microbiota. In other words, unbalanced gut microbiome or intestinal permeability may lead to a loss of integrity of the skin barrier that might trigger predispositions to atopic dermatitis in this case.

Organoids are miniaturized in vitro organ models that are derived from stem cells. They can be established from two sources of cells: adult stem cells (ASCs) or induced pluripotent stem cells (iPSCs). The organoids are formed by generating 3D aggregate through the cell culture.

Cystic fibrosis is an inherited disease that causes a buildup of thick mucus in the lungs, leading to repeated bacterial infections that damage the lungs and can cause respiratory failure.

Adding to this problem when the bacterial infection become resistant bacteria the treatment of the patient become really challenging.