Find out more on articles related to infectious diseases : Bacteria - virus - fungi.
Acne vulgaris is a common inflammatory disorder affecting more than 80% of young adolescents. Cutibacterium acnes plays a role in the pathogenesis of acne lesions, although the mechanisms are poorly understood.Vibiosphen
Recent advances in sequencing technology have demonstrated that the development of AD not only associates with the skin microbiome, but also with gut microbiota. In other words, unbalanced gut microbiome or intestinal permeability may lead to a loss of integrity of the skin barrier that might trigger predispositions to atopic dermatitis in this case.Vibiosphen
Organoids are miniaturized in vitro organ models that are derived from stem cells. They can be established from two sources of cells: adult stem cells (ASCs) or induced pluripotent stem cells (iPSCs). The organoids are formed by generating 3D aggregate through the cell culture.Vibiosphen
Cystic fibrosis is an inherited disease that causes a buildup of thick mucus in the lungs, leading to repeated bacterial infections that damage the lungs and can cause respiratory failure.
Adding to this problem when the bacterial infection become resistant bacteria the treatment of the patient become really challenging.Vibiosphen
On the one hand, antibiotics are one of the most powerful tools to save lives. The breakthrough that saved many lives also gets its dark side. Despite the decreasing efficacy in the treatment of patients and the rise of resistance due to the misuse of antibiotics and not of antibiotics themselves, scientists have found a real downside: the impact on the gut microbiota.
“a growing number of studies are finding that even a short course of antibiotics can alter the makeup of the bacterial species in the gut.”Vibiosphen
A direct link between climate change and infectious diseases can be explained by one notion: the one health concept.
As a reminder, the one health concept is a concept that stand for the interconnection of human – animal and environment health. Dysregulating one aspect can have an impact on others. In this specific case, the three notions of health are interconnected. As a consequence of climate change, scientists predict that wild animals will be forced to relocate their habitats and will most likely be closer to human population or to farmed animals.Vibiosphen
A valid animal model of SARS-CoV-2 infection and its complications might shed light on the pathophysiology of the disease and can be used for assessing the efficacy and safety of novel antiviral compounds.
At Vibiosphen, we reproduced a mouse model of SARS-CoV-2 infection  and modified it to better define key post-infection immunological abnormalities. For this purpose, 7-week-old transgenic (K18-hACE2)2Prlmn male mice were intranasally challenged with a lethal dose (200 PFU/mouse) of SARS-CoV-2 (Wuhan strain).Vibiosphen
In almost 1 / 4 of the sites monitored worldwide, the concentrations of medicine found in rivers exceed the levels recommended preserving aquatic biodiversity or to prevent antibiotic resistance: that is one of the outcomes of a study performed through the University of York (United Kingdom), in collaboration with 86 studies institutes, including the National Research Institute for Agriculture, Food and the Environment (Inrae) in France.Vibiosphen
The silent pandemic threat is now well known in the field of infectious disease, but yet still few new antimicrobials are coming on the market. Even if a recent study showed that in 2019, 1,2 Million death was due to resistant bacterial infections and thus more death was attributed to bacterial infection than HIV or Malaria.Vibiosphen
Antimicrobial resistance (AMR) is often viewed as a concept but not as a reality. Highlighting stories of real-life dramatic patient AMR is essential for sensibilization.Vibiosphen
Nowadays, we face the Covid-19 pandemics but under our radar the silent pandemic is rising. It is common to hear about the outbreaks of flu, malaria, or outbreaks from new Covid-19 variant. It is less common to heard about the outbreaks of antimicrobial resistance (AMR) referred as the silent pandemic.Vibiosphen
The one health concept intends to avoid new pandemics by having a systemic point of view of the situation. We can take the concept as a two pillars solution. On the one hand by controlling the exposition of livestock with wildlife to reduce the cross-contamination and on the other hand by controlling the risk of emerging diseases inside the livestock.Vibiosphen