Human Lung Organoïds, an innovative preclinical model of pulmonary infections
Organoïd are a relevant tools to slide between the in vitro studies and the in vivo studies, thanks to the human cells structure.
Lung organoïd model
Organoids are three-dimensional (3D) multicellular in vitro self-assembled constructs that mimic the corresponding in vivo organ in terms of cell type, structure and function.
Organoids are functional units generated by seeding pluripotent or induced pluripotent stem cells onto extracellular matrix solution and adding the appropriate growth factors for cells to differentiate into the lineage of interest in the growing organoid.
Lung organoid cultures have led to new physiological in vitro models that better mimic the lung than conventional 2D cultures. Pulmonary infectious diseases are being developed in models of organoids microinjected with pathogenic microorganisms.
Human primary cells
Organoids are three-dimensional (3D) multicellular in vitro self-assembled constructs that mimic the corresponding in vivo organ in terms of cell type, structure and function.
Organoids are functional units generated by seeding pluripotent or induced pluripotent stem cells onto extracellular matrix solution and adding the appropriate growth factors for cells to differentiate into the lineage of interest in the growing organoid.