Bacteriocins a potential alternative to antibiotics


Bacteriocins, also known as antimicrobial peptides, are produced naturally by bacteria. Bacteriocins have antimicrobial activity against bacteria closely related to the producer strain in order to protect their ecological niche.

AMPs are ribosomally synthesized by gram-positive (Lactobacillus, Lactococcus, Streptococcus, Enterococcus, Leuconostoc, Pediococcus, and Propionibacterium), gram-negative (Escherichia coli, Shigella, Serratia, Klebsiella, and Pseudomonas), and archaea. 
The principal mode of action is to target a certain type of bacteria to degrade its cell membrane (loss of water and electrolytes and change in osmolarity will kill bacteria). 

Bacteriocin has historically been used in the food industry to avoid the colonization of unwanted bacteria.  But now that broad-spectrum antibiotics are showing a lack of efficacy, the narrow spectrum of bacteriocin has shown interest in the development of therapy. AMP enters along with bacteriophage therapy to the arsenal of alternatives to tackle antimicrobial resistance. 

This study allows us to learn more about the potential bacteriocins.